Calcium Folinate

Brief Introduction:

Calcium folinate is an antidote to folic acid antagonists, also known as folic acid calcium, folic acid calcium, aldehyde hydrogen folic acid calcium, acetic acid, folic acid calcium, and formyltetrahydrofolic acid calcium. It is a slightly yellowish white to yellow crystalline or amorphous powder at room temperature, odorless. Easily soluble in water, almost insoluble in ethanol or ether, and easily soluble in sodium hydroxide solution. Calcium folinate is a reduced formylation derivative of folic acid, which acts similarly to folic acid and is an activated form of folic acid in the body. After entering the human body, tetrahydrofolate reductase is converted into tetrahydrofolate, which can effectively combat the toxic reactions caused by methotrexate. Calcium folinate has the ability to "rescue" the toxic reactions of excessive folic acid antagonists in the body, which is beneficial for thymidine chemonucleotides, DNA, RNA, and even protein synthesis, and can stimulate the growth and maturation of white blood cells. This product can limit the degree of damage caused by methotrexate to normal cells, through mutual competition, and can reverse the reactions of methotrexate to bone marrow and gastrointestinal mucosa, but has no effect on the existing neurotoxicity of methotrexate. Mainly used as an antidote for folic acid antagonists such as methotrexate, methotrexate, phenytoin sodium, phenobarbital, pyrimidine or trimethoprim. When oral folic acid has poor efficacy, it is used for oral inflammatory diarrhea, malnutrition, megaloblastic anemia caused by pregnancy or infancy, and leukopenia. But it is not suitable for vitamin B12 deficiency anemia.